Dichotomous Effects of Chronic Intermittent Hypoxia on Focal Cerebral Ischemic Injury

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Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury.

BACKGROUND AND PURPOSE Obstructive sleep apnea, a condition associated with chronic intermittent hypoxia (CIH), carries an increased risk of stroke. However, CIH has been reported to either increase or decrease brain injury in models of focal cerebral ischemia. The factors determining the differential effects of CIH on ischemic injury and their mechanisms remain unclear. Here, we tested the hyp...

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ژورنال

عنوان ژورنال: Stroke

سال: 2014

ISSN: 0039-2499,1524-4628

DOI: 10.1161/strokeaha.114.004816